ea0028p290 | Reproduction | SFEBES2012
Sadraie Maryam
, Hastings Julie
, Mullins Linda
, Mullins John
, Morley Steven
, Kenyon Christopher
We have investigated cell proliferation and apoptosis in Cyp11b1 null (ko) mice. Reduced glucocorticoid (corticosterone) synthesis in ko mice is associated with increased progesterone and deoxycorticosterone and the development of adenomyosis. Numbers of putative uterine stem cells were assessed in wild type (wt) and ko at an age (1012 months) when the onset of adenomyosis was considered imminent. Mice were infused with bromodeoxyuridine (BrdU) for seven days then killed...